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healthy skin fibroblasts  (PromoCell)


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    Structured Review

    PromoCell healthy skin fibroblasts
    ATP production capacity of LS patient-derived skin <t>fibroblasts.</t> No significant enhancement of ATP production upon administration of apomorphine, D31, D55, or D40.
    Healthy Skin Fibroblasts, supplied by PromoCell, used in various techniques. Bioz Stars score: 98/100, based on 936 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/healthy skin fibroblasts/product/PromoCell
    Average 98 stars, based on 936 article reviews
    healthy skin fibroblasts - by Bioz Stars, 2026-03
    98/100 stars

    Images

    1) Product Images from "Synthetic aporphine alkaloids are potential therapeutics for Leigh syndrome"

    Article Title: Synthetic aporphine alkaloids are potential therapeutics for Leigh syndrome

    Journal: Scientific Reports

    doi: 10.1038/s41598-024-62445-w

    ATP production capacity of LS patient-derived skin fibroblasts. No significant enhancement of ATP production upon administration of apomorphine, D31, D55, or D40.
    Figure Legend Snippet: ATP production capacity of LS patient-derived skin fibroblasts. No significant enhancement of ATP production upon administration of apomorphine, D31, D55, or D40.

    Techniques Used: Derivative Assay

    GDF-15 suppression in RSL3 loaded LS fibroblasts of D31, D55, and D40. Compared to the RSL3-only, the groups co-administered with apomorphine, ferrostatin-1, D31, D55, and D40 showed a significant decrease in the concentration of GDF-15 in cell supernatant of LS patient-derived skin fibroblasts.
    Figure Legend Snippet: GDF-15 suppression in RSL3 loaded LS fibroblasts of D31, D55, and D40. Compared to the RSL3-only, the groups co-administered with apomorphine, ferrostatin-1, D31, D55, and D40 showed a significant decrease in the concentration of GDF-15 in cell supernatant of LS patient-derived skin fibroblasts.

    Techniques Used: Concentration Assay, Derivative Assay



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    Image Search Results


    ATP production capacity of LS patient-derived skin fibroblasts. No significant enhancement of ATP production upon administration of apomorphine, D31, D55, or D40.

    Journal: Scientific Reports

    Article Title: Synthetic aporphine alkaloids are potential therapeutics for Leigh syndrome

    doi: 10.1038/s41598-024-62445-w

    Figure Lengend Snippet: ATP production capacity of LS patient-derived skin fibroblasts. No significant enhancement of ATP production upon administration of apomorphine, D31, D55, or D40.

    Article Snippet: Healthy skin fibroblasts purchased from Promo Cell GmbH (#C-12300; Heidelberg, Germany) were used as controls.

    Techniques: Derivative Assay

    GDF-15 suppression in RSL3 loaded LS fibroblasts of D31, D55, and D40. Compared to the RSL3-only, the groups co-administered with apomorphine, ferrostatin-1, D31, D55, and D40 showed a significant decrease in the concentration of GDF-15 in cell supernatant of LS patient-derived skin fibroblasts.

    Journal: Scientific Reports

    Article Title: Synthetic aporphine alkaloids are potential therapeutics for Leigh syndrome

    doi: 10.1038/s41598-024-62445-w

    Figure Lengend Snippet: GDF-15 suppression in RSL3 loaded LS fibroblasts of D31, D55, and D40. Compared to the RSL3-only, the groups co-administered with apomorphine, ferrostatin-1, D31, D55, and D40 showed a significant decrease in the concentration of GDF-15 in cell supernatant of LS patient-derived skin fibroblasts.

    Article Snippet: Healthy skin fibroblasts purchased from Promo Cell GmbH (#C-12300; Heidelberg, Germany) were used as controls.

    Techniques: Concentration Assay, Derivative Assay

    Generation of iPSCs from patient-derived skin fibroblasts. ( A ) Representative phase contrast images of CTL, AMN, and cALD iPSCs. ( B ) Representative alkaline-phosphatase-stained images of CTL, AMN, and cALD iPSCs. ( C ) Immunostaining for pluripotency markers: NANOG, TRA1–60, SOX2, and SSEA. Nuclei are stained with DAPI (blue). ( D ) RT-qPCR quantification of pluripotency markers (ratio against L27) in CTL, AMN iPSCs ( n = 3). ( E ) Representative immunocytochemistry showed iPSC-derived cells positive for markers of three germ layers following differentiation: endoderm (SOX17), mesoderm (BRACHYURY and DESMIN), ectoderm (OXT2 and TUBB3). AMN: Adrenomyeloneuropathy; cALD: Cerebral adrenoleukodystrophy; CTL: Control; iPSC: Induced pluripotent stem cell. Scale: 100 µM ( A , B ) and 50 µM ( C , E ).

    Journal: International Journal of Molecular Sciences

    Article Title: Generation and Characterization of Human iPSC-Derived Astrocytes with Potential for Modeling X-Linked Adrenoleukodystrophy Phenotypes

    doi: 10.3390/ijms26041576

    Figure Lengend Snippet: Generation of iPSCs from patient-derived skin fibroblasts. ( A ) Representative phase contrast images of CTL, AMN, and cALD iPSCs. ( B ) Representative alkaline-phosphatase-stained images of CTL, AMN, and cALD iPSCs. ( C ) Immunostaining for pluripotency markers: NANOG, TRA1–60, SOX2, and SSEA. Nuclei are stained with DAPI (blue). ( D ) RT-qPCR quantification of pluripotency markers (ratio against L27) in CTL, AMN iPSCs ( n = 3). ( E ) Representative immunocytochemistry showed iPSC-derived cells positive for markers of three germ layers following differentiation: endoderm (SOX17), mesoderm (BRACHYURY and DESMIN), ectoderm (OXT2 and TUBB3). AMN: Adrenomyeloneuropathy; cALD: Cerebral adrenoleukodystrophy; CTL: Control; iPSC: Induced pluripotent stem cell. Scale: 100 µM ( A , B ) and 50 µM ( C , E ).

    Article Snippet: Healthy human skin CTL fibroblasts (GM08402; 32-year-old male, GM03348; 10-year-old male), AMN fibroblasts (GM17819; 32-year-old male, GM07675; 22-year-old male), and cALD fibroblasts (GM04904; 11-year-old male, GM04496; 6-year-old male) were obtained from the National Institute for General Medical Sciences human genetic cell repository at Coriell Institute for Medical Research, Camden, NJ, USA.

    Techniques: Derivative Assay, Staining, Immunostaining, Quantitative RT-PCR, Immunocytochemistry, Control